The prestigious master-planned community of Northpark features three 24 hour guard gates, 5 resort pools, 3 lighted tennis courts, 1 basketball court, numerous sport courts and playgrounds, clubhouse, community parks and trails. The backyard is perfect for entertaining w/stone seat wall & relaxing water feature. This home is recently upgraded with laminate floor on the ground floor. This space can be used as a guest suite, home office, or home gym.
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and has a closet and a gorgeous full bathroom. There's another bedroom located above the garage with it's own private stairway. There are also 2 large secondary bedrooms and shared bathroom. The front bedroom wing has a master bedroom suite, walk-in closet & luxurious master bath w/custom tile-work & separate shower.
![chef chen irvine chef chen irvine](https://www.sparkoc.com/wp-content/uploads/sites/www.sparkoc.com/images/2020/11/Yong-Chen-Convo-Kitchen-Banner-uci-768x409.jpg)
The great room also features a built-in media center, inviting fireplace, dining area & built-in desk. Continue through the downstairs to the stunning open concept great room featuring a chef's kitchen with large center island, newer high-end stainless steel appliances & granite counters. Enter this incredible home's foyer and discover an elegant living room. This 4 bedroom, 3.5 bathroom home has a unique floor plan. This Remarkable Northpark Home built by California Pacific encompasses approx. The great room also features a built-in media center, inviting. Chen was the co-inventor of a diagnostic test for this virus currently used in blood banks throughout the world.This Remarkable Northpark Home built by California Pacific encompasses approx. Chen also was instrumental in identifying HTLV II, a human T-cell leukemia virus.
![chef chen irvine chef chen irvine](https://10619-2.s.cdn12.com/rests/original/409_2694055.jpg)
Along with his exploration of the disease-causing process of the AIDS virusHIV (human immunodeficiency virus), Dr.
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This form of virus reproduces by creating DNA from RNA and adding its genetic code to the chromosomes of the cells it has infected. Chens focus is on human retroviruses that are implicated in cancer and AIDS. Chen, Director of the UCLA AIDS Institute, is Professor of Microbiology, Immunology, Molecular Genetics and Professor of Medicine at the David Geffen School of Medicine at UCLA, and is an internationally recognized retrovirologist and molecular biologist. This is the only model for human stem cell gene therapy, and allows for more rapid experimental design of vectors, reagents, etc.ĭr. We are modeling gene therapy utilizing the SCID-hu mouse for introduction of “protected” CD34+ stem cells, reconstitution of the SCID-hu animal and finally, challenge with HIV-1. However, the new T-cells need to be protected from the effects of residual HIV-1. Immune reconstitution is theoretically a viable approach to AIDS therapy. We are investigating the role of this gene, termed vpr, and the specific cell cycle kinases, cyclins and cell cycle inhibitors that may be involved in this process. Furthermore, this ability of HIV-1 to arrest T-cells can be abrogated by specific mutations within one of the non-structural genes of the virus. We have found that HIV-1 causes perturbation of the cell cycle, leading to arrest of the cells at a particular point in the cycle. The mechanism by which HIV-1 causes CD4+ T-cell death is unknown. Some of the specific projects ongoing in this laboratory are: 1. We are also developing gene therapy reagents and modeling these reagents utilizing the SCID-hu mouse, which allows stem cell reconstitution and thymic T-cell development. The overall research interests of this laboratory are to understand, at the molecular and cellular levels, how the human retroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus (HTLV), cause AIDS and cancer, respectively. Member, CTSI, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)
![chef chen irvine chef chen irvine](https://food.fnr.sndimg.com/content/dam/images/food/fullset/2011/6/14/1/CART_Star-Challenge-Orchid-Paulmeier-and-Duff-Goldman_s4x3.jpg)
Professor, Microbiology, Immunology & Molecular Genetics Co-Leader, Pilot and Collaborative Translational Clinical Studies Program